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Kim and Gladyshev, 2004

It suggests the potential for a systemic response, which is pretty amazing, she says

In view of the above, this paper provides an overview of the research conducted on the delivery of anticancer drug-loaded chitosan-based nanoparticles incorporated into inhaled drug delivery devices for the treatment of lung cancer

Surprisingly it has been proposed that besides inhibiting the proteasome, lipofuscin may also be able to inhibit lysosomal proteases [227]
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