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The FDA approval process for peptides involves multiple phases

This is dependent on the 3-4-fold increase in total IGF-I (50), which consequently results in an increase in unbound IGF-I, even if the increase is matched with the same absolute molar increase in IGFBP-3 (and complexed with ALS in a ternary complex)
Reported mechanisms should be read as hypotheses from laboratory and animal data

Apr 2013;20(4):616-22
