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Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T, et al

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the GR has a modular structure mainly consisting of a central DNA binding domain (DBD), nuclear localization signals, a ligand binding domain (LBD), and several transcription activation functions

its blood concentration is usually inversely associated with blood concentrations of thyroid hormones) was stronger in women with iodine deficiency (measured as urine iodine concentration (UIC)) than in iodine sufficient women, and also stronger in smoking women, the last association being probably due to the action of thiocyanates (present in cigarette smoke) that also inhibit iodine uptake [57, 58]

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