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Oxidative distress causes damage to fundamental macromolecules including proteins, lipids, RNA and DNA at a cellular level, which promotes abnormal cell death and inflammation, often culminating in additional oxidative stress at a systemic level

[DOI] [Google Scholar] 28.Khavinson V.K., Rybakina E.G., Malinin V.V., Pivanovich I.Y., Shanin S.N., Korneva E.A

beta-catenin siRNA regulation of apoptosis- and angiogenesis-related gene expression in hepatocellular carcinoma cells: potential uses for gene therapy

For example, the nebulized formulation of recombinant human SOD can specifically neutralize O2 within lung tissue, directly targeting the sites of inflammation

Others report no noticeable improvement after months of consistent use