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This addresses the poor aqueous stability of LF and its high excretion through the nasolacrimal duct, which can affect its therapeutic efficacy

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Modern trends in pharmacopsychiatry 31 , 152161, (2017)

Mitochondrial dysfunction in ME/CFS Mitochondrial dysfunction is implicated as a key pathogenic process in ME/CFS, underpinned by mechanisms involving oxidative and nitrosative stress, immune-inflammatory pathways, and metabolic disturbances