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Surgery (hemorrhoidectomy) is generally reserved only for the most severe cases which cannot be managed with simpler means

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While GHK has been shown to inhibit the inflammatory response and epithelial-mesenchymal transition (EMT) via the TGF-1/Smad 2/3 and IGF-1 pathways in bleomycin-induced fibrosis models [24], its broader anti-inflammatory effects in the context of pulmonary fibrosis pathogenesis may warrant further exploration