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[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Decker-Baumann C., Buhl K., Frohmller S., von Herbay A., Dueck M., Schlag P.M
Moreover, in conditions not directly caused by flavoprotein gene mutationssuch as L-2-hydroxyglutaric aciduria (L2HGA) or Friedreichs ataxia (FRDA)metabolic pathology often involves secondary dysfunction of FAD-dependent enzymes and redox disruption

As a result, many of the children became severely anaemic and increasingly prostrated, and about 10% of the G6PD-deficient hemizygous males had to be rescued by blood transfusion

Acknowledgments The authors acknowledge the use of BioRender to create schematic representations in Figures 1 3

A growing body of evidence points to a significant link between migraine and disruptions in brain energy metabolism (5)