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Interruption of Triacylglycerol Synthesis in the Endoplasmic Reticulum Is the Initiating Event for Saturated Fatty Acid-Induced Lipotoxicity in Liver Cells

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

Apo E is crucial for this process and mutations in Apo E (for example homozygosity for the Apo E2 isoform) can result in decreased chylomicron clearance and elevations in plasma cholesterol and triglyceride levels (familial dysbetalipoproteinemia) (30)

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