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Studies were done at the NBRL between 1968 to 1974 to document that patients with chronic hypovolemic anemia following traumatic injuries and patients with cardiopulmonary insufficiency had red blood cells with increased levels of RBC 2,3 DPG and RBC creatine

(10) Also excluded were those who had received liver function-enhancing medications, antibiotics, choleretic agents, antioxidants, or dietary supplements within 14 days of the first dose of the investigational product, or who did not agree to abstain from such medications from 14 days to the end of the study, (11) and those who had received drugs that induce or inhibit drug metabolizing enzymes, such as barbiturates, within 30 days of the first dose of the investigational product, or who did not agree to abstain from such drugs from 30 days to the end of the study

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Psychiatry Research , 265 , 6269

However, the results could vary from person to person, depending on individual factors, skin condition, and genetic considerations