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Certain Medications Long-term use of medications such as metformin (for diabetes) and proton pump inhibitors or antacids (for acid reflux) can interfere with vitamin B12 absorption over time

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doi: 10.3389/fphar.2023.1122632 Received 13 December 2022 Accepted 13 March 2023 Published 27 March 2023 Volume 14 - 2023 Edited by Enrico Sangiovanni, University of Milan, Italy Reviewed by Ayaz Shahid, Western University of Health Sciences, United States Andres A

Oral glutathione has poor bioavailability (10-15% absorption)

Its removal from Category 1 means it is moving into the PCAC review pipeline for a definitive determination rather than remaining in the indefinite "under evaluation" holding pattern