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Description
This effect is blocked by glutamatergic antagonist CNQX [cyanquixaline (6-cyano-7-nitroquinoxaline-2,3-dione)] and AP5 (2-amino-5-phosphopentanoic acid), suggesting that interneuron-astrocyte-mediated potentiated inhibition of pyramidal neurons depends on astrocyte-mediated glutamate release (Kang et al., 1998)
These processes are both involved in the pathogeneses of AD

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R.HoeftS

Therefore, the Fbx2 E3 ligase could be another potential target for AD treatment
