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Physician-initiated first-in-human clinical study using a novel angiogenic peptide, AG30/5C, for patients with severe limb ulcers

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Genetic predisposition plays a central role in breaking immune tolerance to self-antigens

Author Contributions C.G.-M.: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writingoriginal draft, Writingreview and editing

Thus, the GVB barrier controls the translocation of antigens of various sizes from the gut into the bloodstream and, in particular, prevents the penetration of intestinal microbiota into the portal bloodstream (Spadoni et al., 2015)