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In the context of obesity, the accumulation of free fatty acids in joints leads to organ lipotoxicity, and rising lipid levels contribute to the occurrence of KOA, with consequent tissue inflammation [12]

Furthermore, the depletion of 5-HT caused by the activation of the kynurenine pathway also plays a significant role in the onset of depressive symptoms

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Related: Dog Joint Pain 101: Causes & Risk Factors Where to Get High-Quality L-Carnitine for Pets Choosing a reliable source for supplements matters
