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Interestingly, deficiencies in dietary B6 vitamin further increases DNA hypomethylation in carriers of low activity genetic variants of MTHFR (27)

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In contrast, coal-derived CQDs exhibited potent inhibition of SARS-CoV-2 replication in vitro , achieving more than 95% reduction in viral growth at half-maximal inhibitory concentration (IC 50 ) of approximately 5.47 g/mL, with minimal cytotoxicity in normal cell lines, indicating genuine antiviral activity in a human-relevant viral system [123]