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Adverse effects of GLP-1 receptor agonists such as dulaglutide include gastrointestinal disturbance and injection site reactions Sodium-glucose co-transporter 2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists have been recommended internationally in type 2 diabetes management guidelines for some time, but, until now, have been inaccessible to most people in New Zealand due to cost

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Major insulin signaling pathways in the brain When insulin binds to its receptor, it activates two major intracellular signaling pathways, which regulate key brain functions, including neurotransmission, metabolism, energy balance, and neuronal survival [Figure 1]

Sleep disorders: Sleep deprivation and conditions such as Obstructive Sleep Apnea (OSA) can affect hormone synthesis, particularly Testosterone, resulting in reduced sex drive

"Retatrutide in Patients with NAFLD: A Randomized Phase 2 Trial." Hepatology/AASLD.(Confirms that lower doses are highly effective for metabolic/liver health)