tirzepatide how to stop taking Wean Off Tirzepatide: Safe Discontinuation Guide How do you wean off?

Zepbound (tirzepatide) is a GIP and GLP-1 agonist that works in the treatment of people with obesity or with excess weight and weight-related medical problems by activating the receptors for the natural incretin hormones GIP and GLP-1 to decrease food intake and slow gastric emptying

By the time you reach 5.0 mg tirzepatide (typically week 5), most people feel at least as much appetite control as they had on their previous semaglutide dose

Diabetologia 62:665675 [DOI] [PubMed] [Google Scholar] Bergmann NC et al (2020) No acute effects of exogenous glucose-dependent insulinotropic polypeptide on energy intake, appetite, or energy expenditure when added to treatment with a long-acting glucagon-like peptide 1 receptor agonist in men with type 2 diabetes

2023a, b, c, d, e, f

This was accompanied by notable improvements in fasting glucose and insulin sensitivity indices derived from standardized mixed-meal tolerance testing (sMMTT)