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Description
Under pathological stress, macrophages contribute to inflammatory responses, which drive insulin resistance and T2DM

However, humans and mice display large differences

Innovative designs incorporating active comparators, adaptive frameworks, and biomarker-driven endpoints (e.g., CSF/serum NfL, p-tau, microglial PET, synaptic markers) will be critical to generate interpretable efficacy signals

& Miedlich, S

Lancet 2023, 402, 720730
