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Questions regarding the cardiovascular safety of drugs prescribed for T2DM arose as individuals treated with sulfonylureas and insulin showed an increased incidence of major adverse cardiovascular events (MACEs: death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) [18, 19]

Effectiveness and safety of combining SGLT2 inhibitors and GLP-1 receptor agonists in individuals with type 2 diabetes: a systematic review and meta-analysis of cohort studies

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Common gastrointestinal side effects include: Nausea and vomiting : Usually most pronounced during initial treatment and dose escalation, often improving over 48 weeks Diarrhoea or constipation : Can affect hydration and nutritional status Abdominal discomfort : Typically mild and transient Patients can manage mild gastrointestinal symptoms by eating smaller, more frequent meals, avoiding high-fat foods, staying well-hydrated, and taking the medication as directed

Backed by extensive scientific evidence from rigorous clinical trials and corroborated by real-world data showing substantial, sustained fat mass reduction, metabolic improvements, and enhanced quality of life, it serves as a powerful, medically supervised tool