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doi: 10.1007/s00125-023-05962-z

When energy intake drops sharply and fat stores deplete rapidly, the hypothalamic-pituitary axis responds by downregulating processes deemed non-essential for survival
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SELECT showed that group gets significant MACE reduction, which is a mortality-relevant outcome

At baseline, the MBS groups had a mean (SE) BMI of 45.2 (0.2) compared with 46.1 (0.5) for the GLP-1 RA group
