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They found that even when weight loss was completely removed from the equation, semaglutide still reduced liver fat, inflammation, and fibrosis

doi: 10.1001/jamanetworkopen.2024.27258 Summary Keywords comparative effectiveness, glycemic control, narrative review, obesity pharmacotherapy, Semaglutide, tirzepatide, weight loss Citation Harbi MH, Ashour AM, Alorfi NM, Aldurdunji MM, Wali SM and Alzahrani YA (2026) Tirzepatide vs

They work through entirely different mechanisms and have very different risk profiles

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