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Heat increases molecular vibration, breaking peptide bonds and altering the drug's three-dimensional structure

Johns recommends seeing a doctor if you experience severe abdominal pain, nausea or vomiting along with changes in bowel habits

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Treatment persistence was modest overall, with 49.0% of patients remaining on finerenone and 55.5% on spironolactone at 6 months, declining to 33.8% and 28.3% at 12 months, respectively