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Therefore, as delivery technologies continue to evolve, they are expected to differentiate GLP-1 therapies in an increasingly competitive sector

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56 Decreased food intake and weight loss were observed with peripheral administration of GLP-1RAs, but inactivation of intestinal GLP-1 production did not interfere with food intake or weight control, suggesting that the GLP-1R-dependent signaling regulating appetite and body weight occurs in the CNS

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