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Those who moved from Wegovy to orforglipron maintained nearly 80% of their weight loss, compared with just 38% in the placebo group

glucagon suppression, lowering hepatic glucose output Central Nervous System: Decreases food intake by targeting homeostatic and hedonic appetite pathways (hindbrain/hypothalamus), reducing hunger and cravings, and enhancing satiety Gastrointestinal Tract: Delays gastric emptying, contributing to satiety (transient effect at higher doses) Adiposity/Energy Intake : Weight loss is primarily driven by sustained reduction in caloric intake, not increased energy expenditure Biological Activity Potent GLP-1 receptor agonist Enhances insulin secretion (glucose-dependent) Suppresses glucagon secretion Reduces appetite and caloric intake Produces significant, sustained body weight loss Improves cardiometabolic risk factors (glycemia, blood pressure, lipids) Storage Refrigerate once reconstituted

Pickart L, Margolina A

The high cost of insulin continues to concern patients, providers and legislators alike, and pharma companies are attempting to slash prices

But the overall takeaway is that it is challenging to stay on these medications, even in clinical trial conditions