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Additionally, the GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) dual agonist tirzepatide can induce weight loss of 10%20%, and the results of the ongoing SURPASS-CVOT trial may provide more clarity on whether weight loss itself is an independent driver of CV protection (74)

The most potent undecapeptide contains two substituted biphenylalanines at the C-terminus and showed surprisingly high potency as a truncated GLP-1 analog (200-fold decrease)

These effects were mediated by the endothelial nitric oxide synthase (eNOS)/soluble guanylate cyclase/protein kinase G and Rho kinase pathways [84]

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Is tirzepatide or semaglutide better