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Schizophrenia Bulletin, 45, 1300-1308

Independent verification of bioavailability - meaning whether and how much of these ingredients actually reach systemic circulation through transdermal delivery - is not publicly available

Its safety in individuals over 75 years of age is not established

The mechanism(s) by which GLP-1RAs would cause NAION is also unclear, particularly as GLP-1RAs are associated with neuroprotective properties and reductions in ischemic risk (96), but it has been hypothesized to be related, like the exacerbation of retinopathy, to rapid improvements in glycemic control (Figure 3)

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