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People should also make healthy habits a priority, such as staying hydrated, getting enough sleep, and managing stress

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After clinical trials, the FDA approved liraglutide for obesity treatment in 2014, marketed as Saxenda

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Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: the STEP 8 randomized clinical trial

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Celastrol and Withaferin A, as naturally occurring compounds, may act as leptin sensitizers to mitigate the leptin resistance and promote the weight loss [294, 295]

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