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[119] conducted a phase II clinical trial in patients with NASH, that is, a placebo-controlled trial of subcutaneous sommarutide in the treatment of NASH, and found that sommarutide treatment resulted in a significantly higher proportion of patients in remission of NASH compared with placebo

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Obesity alters gut microbial ecology
The primary outcome of this study is the incidence of osteoporosis

In conclusion, gut peptides mediate the crosstalk between the gut microbiota and the host
