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Berberine is unsafe for infants, so it should not be used when pregnant or breastfeeding
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LIRA did not significantly alter soluble guanylyl cyclase or endothelial nitric oxide synthase (eNOS) mRNA levels, nor total myocardial eNOS protein expression
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doi: 10.1016/0196-9781(94)90016-7 108 IrwinNGaultVFlattPR
