semaglutide long term side effects reddit Never thought it was possible until I started semaglutide. : r/PetiteFitness What Reddit, Inc. | Glen

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NICE first recommended the drug in draft guidance 2022, after a clinical trial of just under 2000 volunteers found that people lost on average 12% more weight with semaglutide alongside supervised weight loss coaching (BMJ 2023;380:556)

Fear of invasive procedures, misconceptions about safety, limited access, and insurance barriers all contribute

Growing evidence from observational studies indicates that treatment of obesity with bariatric surgery improves cardiovascular outcomes, but these findings have not been confirmed in randomized trials, largely because of randomization challenges with bariatric surgery