glp-1 receptor agonist function actions and target organs. GLP-1, through its GLP-1R, Science Behind GLP 1 GIP

Curr Diabetes Rev 14(3):273279 Mousavi A et al (2025) Safety, efficacy, and cardiovascular benefits of combination therapy with SGLT-2 inhibitors and GLP-1 receptor agonists in patients with diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

Saxenda may be worth discussing if: You did not tolerate semaglutide or tirzepatide well, and liraglutide offers a different side-effect profile for you specifically You are between 12 and 17 years old and your clinician recommends liraglutide over semaglutide in your case You prefer a daily injection routine over a weekly one for habit or medical reasons You want one of the longest-established track records in the class with over a decade of real-world safety data Mounjaro vs Wegovy: what the head-to-head data actually says For years, comparing Mounjaro and Wegovy meant comparing separate trials in separate patient populations with different designs

In a meta-analysis of GLP-1RA use in T1D, all adverse events were significantly higher in the GLP-1RA group, but there was no difference in serious adverse events (62)

The intra-subject and inter-subject coefficients of variation for sitagliptin AUC were small (5.8% and 15.1%)

Additionally, the prevalent use of GLP-1 agonists was highlighted emphasizing the need for more research in future (91)