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Description
Semaglutide was originally intended for use in diabetic patients through subcutaneous injections
Two participants experienced diarrhoea and abdominal cramping and the dose of metformin was decreased to 1500 mg daily
Semaglutide has a more favorable tolerability profile overall
GLP-1 receptor agonists are typically initiated when lifestyle modifications and first-line oral antidiabetic agents (such as metformin) have not achieved adequate glycaemic control
Peptides (2018) 100:17381.10.1016/j.peptides.2017.11.021 104 ChandraRLiddleRA
