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The addition of the glucagon receptor may explain the enhanced weight loss (28.7% vs 17% for sema******, 22.5% for tirzepatide) and the remarkable 86% liver fat reduction observed in trials

Recent studies have indicated that the protective properties against endothelial dysfunction, anti-inflammatory effects on macrophages and the anti-proliferative action on smooth muscle cells may contribute to atheroprotection through GLP-1R signaling

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GLP-1s can increase insulin production, delay gastric emptying, promote beta-cell proliferation, and decrease appetite

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