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Both modified peptides retain the same sequence as the target peptide, except for the missing amino acids ( Figure 1 )

Tao Y, Ge G, Wang Q, Wang W, Zhang W, Bai J, et al

Br J Pharmacol 166 , 121136, (2012)

BurgmaierMLibermanAMllmannJKahlesFReithSLebherzCet alGlucagon-like peptide-1 (GLP-1) and its split products GLP-1(937) and GLP-1(2837) stabilize atherosclerotic lesions in apoe(-)/(-) mice

Results indicate that DA-JC1 reduces neuroinflammation by inhibiting the proliferation of astrocytes and microglia in the substantia nigra, and mitigates the damage of toxic substances MPTP to midbrain dopaminergic neurons and fibers by promoting the expression of BDNF, phosphorylation of Akt in the PI3K/Akt signaling pathway, downregulating the pro-apoptotic protein Bax, and upregulating the anti-apoptotic protein Bcl2 (109, 110)