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It demonstrated to have a safety profile similar to GLP-1RA not increasing the risk of hypoglycemia ( In the SURPASS-2 study, TZP at the dose of 5, 10, and 15 mg were compared to the GLP-1RA semaglutide (1 mg once weekly) in patients not well controlled in therapy only with metformin ( 1c ( The SURPASS-3 study was started to study the efficacy and safety of TZP versus basal insulin degludec in diabetic patients inadequately controlled by metformin with or without an SGLT2-i for 52 weeks ( In the 52-week SURPASS-4 trial TZP was tested versus insulin glargine in diabetic adults and a high CV risk below not sufficient GC at baseline and in therapy with one to three oral glucose-lowering drugs (metformin, sulfonylurea, SGLT2-i)

Many side effects can be alleviated with medication or simple lifestyle adjustments, such as staying hydrated, replenishing electrolytes, and making dietary changes

Mapping the effectiveness and risks of GLP-1 receptor agonists

This mirrors general weight loss patterns and relates to differences in lean mass, metabolic rate, and hormonal environment

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