weight regain after stopping glp-1 agonists cessation of medication for weight management: systematic review and meta-analysis Weaning Off GLP-1 Medications: A

In spontaneously hypertensive rats, GLP-1 treatment mediates renal vasodilation and attenuates renal autoregulatory responses [68]

Employing preclinical, ex vivo, in vivo, and in vitro model systems investigators determined that GLP-1 agonists exert anti-inflammatory and immune modulating effects through their effects on macrophages (reduced interleukin [IL] 1, IL-6, tumor necrosis factor [TNF], and C-X-C motif chemokine ligand [CXCL]), T and B lymphocytes (reduced cluster of differentiation [CD] 4 cells), monocytes (increased IL-10), mononuclear cells (decreased monocyte chemoattractant protein [MCP]1, cell death protein [PD],, CD4 and CD8 T cells) [5155]

Clinical Application Guidance: Therapeutic selection should be individualized based on patient-specific factors, such as cardiovascular status, renal function, administration route preferences, and tolerability, with ongoing attention to emerging evidence to refine treatment strategies

Care 8 , e001600 (2020)

That last part is crucial