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Titration, the process of slowly increasing dosage over time and only when the medication is well-tolerated, helps manage GLP-1 side effects

GLP-1 receptor agonistsincluding semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)along with tirzepatide (Mounjaro, Zepbound), a dual GIP/GLP-1 receptor agonist, have transformed the management of type 2 diabetes and obesity

Understanding these mechanisms and safety considerations helps patients appreciate why certain effects occur, particularly during the initial treatment phase

Circulating levels of Wegovy, for example, are roughly 230,000 to 760,000 percent higher than the naturally occurring GLP-1 levels that were measured at the end of the Eriomin studies

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