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DKA occurs when severe insulin deficiency leads to uncontrolled lipolysis, excessive ketone production, hyperglycaemia, and metabolic acidosis
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How to manage glycogen-related urination Do not restrict fluids to compensate
15 , 16 , 23 A permanent dose reduction is permitted for management of gastrointestinal adverse events or inadequate oral intake that has not improved with other mitigations, including a prior deescalation and reescalation attempt
