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Abstract Although the multifaceted mechanisms underlying alcohol use disorder (AUD) have been partially defined, the neurobiological complexity of this disorder is yet to be unraveled

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Red-flag symptoms to call your clinician about Severe, persistent abdominal pain, especially radiating to the back (pancreatitis evaluation) Right-upper-quadrant pain, fever, jaundice (gallbladder disease) Severe vomiting, inability to tolerate fluids, or severe constipation/bloating (possible ileus or marked delayed emptying) Black stools or blood in stool/vomit (urgent evaluation) Product labels and FDA communications specify stopping the drug and urgent workup for suspected pancreatitis or gallbladder complications

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