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Some key findings include: According to a head-to-head comparison published in JAMA Internal Medicine in 2024, tirzepatide resulted in an average weight loss of 15.3% after one year, while semaglutide resulted in an average weight loss of 8.3%

doi: 10.1016/j.biopsych.2009.01.029 [DOI] [PMC free article] [PubMed] [Google Scholar] 37.McKee SA, Verplaetse TL

These reports do not establish how common the experience is or prove that tirzepatide is the direct cause

My testosterone is at normal levels for my age

Without lifestyle changes, weight regain is possible
