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Early-stage research continues, but clinical evidence does not yet support patches as a substitute for established injection or oral therapies

In STEP-4 (NCT03548987), maintenance semaglutide after 20 weeks for another 48 weeks led to a further 7.9% bodyweight loss for a total 17.4% weight loss over the whole trial, whereas those who switched to placebo regained an average 6.9% (total weight loss of 5.0%) [66]

compared to baseline in the MO group and only 38% in the PLC group

Side effects: LaValle says that with daily pills, the body experiences a different exposure pattern than with weekly injections, which may lead to varying patterns of nausea or GI upset