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Shumards perspective is not the traditional medical approach, and I dont think every provider will agree with every point he makes

Moreover, the anatomy of the PPG-neuron projections is ideally situated to provide interoceptive information from the hindbrain to the limbic areas mediating the responses to stress (111, 112)

Effects of weight loss in overweight/obese individuals and longterm lipid outcomesa systematic review

The normal caliber of the appendix and absence of appendiceal enlargement, and periappendiceal fluid reduce suspicion for appendicitis and support epiploic appendagitis as the primary diagnosis

However, if nutrition, and hydration havent been changed to accommodate for the medication, then this can make symptoms worse and more persistent