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The development of exendin-4 into the diabetes drug exenatide started the GLP-1RA, or GLP-1 receptor agonist, race

[43] The primary metabolic pathway for melatonin involves cytochrome P450 enzymes, particularly CYP1A2, which may be significantly impaired in patients with severe hepatic dysfunction

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Por otro lado, el efecto antihiperglucemiante de los inhibidores del cotransportador sodio-glucosa tipo 2 (iSGLT2) disminuye a medida que lo hace el filtrado glomerular (FG), con FGe 15ml/min/1,73m2)78

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