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If symptoms worsen, clinicians can compare data to determine causality

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In September 2014, the medication CONTRAVE (naltrexone HCI and bupropion HCI) was approved for use in patients with a body mass index (BMI) of 30 (obesity) or more without weight-related medical conditions or a BMI of 27 or greater with a weight-related medical condition

Treatment effectiveness is assessed at product-specific timepoints, with continuation based on achieving predetermined weight loss targets

This affordability threshold acknowledges that even if a drug passes the cost-effectiveness test, a very large patient group at threshold price could strain the NHS budget