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One large observational study of 461,382 patients taking GLP-1 medications found that 15.1% developed vitamin deficiencies over 12 months, including 13.6% with vitamin D deficiency, 0.0% with niacin deficiency, and 0.1% with thiamine deficiency

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You do have to be careful about who you're seeing and make sure that they're actually knowledgeable about all the risk-benefit profiles, said De Silva

Serious side effects are rare with both, and safety profiles are well-established in millions of users worldwide

Dont forget to evaluate for lifestyle factors and medical causes (diabetes, alcohol abuse, hypothyroidism, pregnancy) and to review the medication list (pay attention to thiazides, non-selective beta blockers, antipsychotics and others)