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Together with Derek Holdsworth, another gastroenterologist trainee, and Desmond Turner, a biochemist, McIntyre decided to revisit La Barre's hypothesis that the duodenum encouraged the pancreas to produce insulin by releasing incretin

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The most important effect of GLP-1 is to increase insulin secretion after a meal, and this effect is dependent on glucose concentration, so despite promoting insulin secretion, the occurrence of hypoglycemia is rare [25]

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Small, repeatable meals can help: protein yogurt, soft eggs, chicken soup, tuna crackers, rice bowls, and gentle snacks