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Description
In the ARISTOTLE [11] trial, apixaban was associated with significantly lower bleeding outcomes than warfarin, except for GI bleeding (for which there was no significant difference between groups)

Even if significant dose volume adjustments are necessary to effectively treat the new condition with a different route of administration and/or dosing, the imputed price (at parity price/unit with the first indication) may not be sufficient to realize the difference in value in the new indication due to higher disease burden, unmet need, or efficacy

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