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The study is important because it confirms that GLP-1RA therapy has clinically meaningful systemic effects, reinforcing the need to understand how metabolic benefit is integrated with broader nutritional and physiological adaptation

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Originally developed for Parkinsons and Alzheimers disease, tesofensine was repurposed for obesity after clinical trials consistently showed significant weight loss as a side effect. By modulating dopamine and serotonin pathways, it reduces food cravings and enhances feelings of fullness while potentially increasing resting metabolic rate