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The synergy between these three systems creates effects greater than any single pathway could achieve alone

doi: 10.1038/s41569-023-00849-3 5 HusainMBainSCJeppesenOKLingvayISrrigRTreppendahlMBet al

10.3233/JAD-201235 Summary Keywords semaglutide, empagliflozin, phosphoproteomic, obesity, cognitive impairment Citation Chen X, Chen S, Li Z, Zhu R, Jia Z, Ban J, Zhen R, Chen X, Pan X, Ren Q, Yue L and Niu S (2023) Effect of semaglutide and empagliflozin on cognitive function and hippocampal phosphoproteomic in obese mice

Patients requiring multifactorial risk management : Individuals with multiple cardiovascular risk factors may benefit from the pleiotropic effects of GLP-1 therapy, including blood pressure reduction, weight loss, and lipid improvements

Research from the Mayo Clinic's sports cardiology division found that GLP-1 receptor agonists delay gastric emptying by 6090 minutes, which means glucose availability during sustained aerobic effort drops significantly if fueling strategies aren't recalibrated