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Major and mild cognitive impairment A total of 525 patients (1.5%) were registered with a diagnosis of major CI, while 79 patients (0.2%) were diagnosed with mild CI

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In the multivariable Cox proportional hazard regression model adjusted for sex, age, marital status, duration of diabetes, hemoglobin A1c, estimated glomerular filtration rate, cardiovascular disease, use of insulin, use of cholesterol lowering medicine, and use of blood pressure lowering medicine, exposure to once-weekly semaglutide also was independently associated with a higher risk of upcoming NAION (HR 219, 95% CI 154 312)