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The "Dehydration Cascade": How GLP-1s May Cause Clots Unlike gastroparesis, which is a direct effect of the drug on the stomach muscles, DVT is often a secondary complication caused by how the drug affects your hydration levels and blood viscosity

doi:10.1152/physiol.00030.2005

Semaglutide, which is the same active ingredient found in Ozempic and Wegovy, and tirzepatide, the active ingredient in Mounjaro and Zepbound

The combination of tirzepatide and metformin is most appropriate for specific patient populations where both medications' complementary mechanisms address clinical needs

The activation of the cGAS-STING pathway has been confirmed to mediate the progression of synovitis and joint destruction by promoting the migration and invasion of fibroblast-like synoviocytes (FLS) and the production of inflammatory factors [22, 46]